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Record 1 of 42
| Record #: | 30 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-dihydroxybenzoic acid (DHB) (490-79-9) |
| Salt: | sodium perchlorate (NaClO4); sodium iodide (NaI); sodium bromide (NaBr); or sodium chloride (NaCl) |
| Solvent: | tetrahydrofuran |
| Recipe | N/A |
Jackson, C.; Larsen, B.; McEwen, C., Comparison of Most Probable Peak Values as Measured for Polymer Distributions by MALDI Mass Spectrometry and by Size Exclusion Chromatography, Analytical Chemistry, 68, 8, 1996, 1303-1308.
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Record 2 of 42
| Record #: | 33 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | trans-3-Indoleacrylic acid (29953-71-7) |
| Salt: | silver trifluoroacetate |
| Solvent: | tetrahydrofuran |
| Recipe | 0.5 µL of 0.1 M solution of matrix in 50/50 acetone/water solution with salt is deposited on stainless steel slide. Solvents are allowed to evaporate under a stream of air with occasional stirring to induce fine crystal growth. PMMA sample is diluted with THF to concentration of 1 mg/mL. 0.5 µL of PMMA solution is deposited on top of matrix and solvent is evaporated. |
Schweer, J.; Sarnecki, J.; Mayer-Posner, F.; Müllen, K.; Räder, H.J.; Spickermann, J., Pulsed-Laser Polymerization/Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry: an Approach Toward Free-Radical Propagation Rate Coefficients of Ultimate Accuracy?, Macromolecules, 29, 13, 1996, 4536-4543.
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Record 3 of 42
| Record #: | 780 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrices: | dithranol (1143-38-0) surface-modified amorphous titanium(IV) oxide (TiO2) nanoparticles (13463-67-7) |
| Salt: | N/A |
| Solvent: | 2-propanol/methanol (titania); (dithranol) |
| Recipe | 0.6 µL portions of the fluid dispersion of TiO2 nanoparticles and the analyte solutions were each put on a stainless-steel sample target and dried at room temperature. |
Watanabe, T.; Okumura, K.; Nozaki, K.; Kawasaki, H.; Arakawa, R., Selective Photocatalytic Degradation of Poly(Ethylene Glycol) Additives Using TiO2 Surface-Assisted Laser Desorption/Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 23, 23, 2009, 3886-3890.
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Record 4 of 42
| Record #: | 1063 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-DHB (490-79-9) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | 2,5-dihydroxybenzoic acid (300 mg, 1.8 mmol) was dissolved in acetone (3 mL), and then sodium trifluoroacetate (3 mg, 0.022 mmol) was added to the solution. Sample solution was prepared by dissolving methylated product (PMMA, 0.01 g) in THF (1 mL). The sample solution (1 μL) was added to matrix solution (10 μL). Then, the solution was loaded onto a stainless steel sample plate (about 100 μm spot size of simple), and the solvents were evaporated. |
Saito, Y.; Saito, R., The Effect of the Distance Between Neighboring Vinyl Groups on Template Polymerization, Polymer, 52, 16, 2011, 3565-3569.
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Record 5 of 42
| Record #: | 170 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 4-hydroxybenzylidenemalononitrile (3785-90-8) |
| Salt: | sodium chloride |
| Solvent: | tetrahydrofuran, acetone, water |
| Recipe | 4-Hydroxybenzylidenemalononitrile was used as the matrix. Samples were made up by a simple 1:1:1 mixture of polymer in concentrations of about 1 mg mL-1 in THF with 10 mg mL-1 matrix in THF and 1 mg mL-1 sodium chloride in a 1:1 mixture of acetone and water. |
Barner-Kowollik, C.; Vana, P.; Davis, T.P., Laser-Induced Decomposition of 2,2-Dimethoxy-2-Phenylacetophenone and Benzoin in Methyl Methacrylate Homopolymerization Studied via Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, Journal of Polymer Science Part A: Polymer Chemistry, 40, 5, 2002, 675-681.
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Record 6 of 42
| Record #: | 669 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium acetate |
| Solvent: | chloroform (matrix, polymer); methanol (salt) |
| Recipe | All solutions were prepared at a concentration of 10 mg mL−1. The matrix and PMMA samples were dissolved in chloroform (Fisher) and mixed in a matrix-to-analyte ratio of 5:1. Fifty microlitres of this solution was mixed with 1 μL of a solution of sodium acetate in HPLC grade methanol, prior to deposition of approximately 0.5 μL on the sample plate. |
Jackson, A.T.; Bunn, A.; Chisholm, M.S., Utilising Matrix-Assisted Laser Desorption/Ionisation Techniques for the Generation of Structural Information from Different End-Group Functionalised Poly(Methyl Methacrylate)s, Polymer, 49, 24, 2008, 5254-5261.
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Record 7 of 42
| Record #: | 32 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | trans-3-Indoleacrylic acid (29953-71-7) |
| Salt: | N/A |
| Solvent: | chloroform or acetone |
| Recipe | Approximately 0.2 µL of a solution of NaI in acetone (10 mg/ mL) is applied to sample stage. Solutions of polymer and matrix in solvent are prepared at concentration of 10 mg/mL. Polymer and matrix solutions are mixed in 1:10 ratio (v/v). |
Larsen, B.S.; Simonsick, W.J.; McEwen, C.N., Fundamentals of the Application of Matrix-Assisted Laser Desorption Ionization Mass Spectrometry to Low Mass Poly(Methylmethacrylate) Polymers, Journal of the American Society of Mass Spectrometry, 7, 3, 1996, 287-292.
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Record 8 of 42
| Record #: | 777 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 4-hydroxy-α-cyanocinnamic acid (28166-41-8) |
| Salt: | N/A |
| Solvent: | 1:1 (v/v) acetonitrile: water with 1% trifluoroacetic acid |
| Recipe | Both matrices 4-hydroxy-α-cyanocinnamic acid and sample were dissolved in 1:1 (v/v) acetonitrile: water with 1% trifluoroacetic acid. A total of 0.5 μL of this mixture solution was placed on a metal sample plate. The sample was air-dried at ambient temperature. |
Wang, W.X.; Zhang, Z.B.; Zhu, J.; Zhou, N.C.; Zhu, X.L., Single Electron Transfer-Living Radical Polymerization of Methyl Methacrylate in Fluoroalcohol: Dual Control Over Molecular Weight and Tacticity, Journal of Polymer Science Part A: Polymer Chemistry, 47, 22, 2009, 6316-6327.
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Record 9 of 42
| Record #: | 1061 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 4-hydroxy-α-cyanocinnamic acid (28166-41-8) |
| Salt: | N/A |
| Solvent: | 1:1 (v/v) acetonitrile: water with 1% trifuoroacetic acid |
| Recipe | Both matrix, 4-hydroxy-α-cyanocinnamic acid, and the sample were dissolved in 1:1 (v/v) acetonitrile: water with 1% trifuoroacetic acid. This mixture solution (0.5 μL) was placed on a metal sample plate. The sample was air-dried at ambient temperature. |
Chen, Q.F.; Zhang, Z.B.; Zhou, N.C.; Cheng, Z.P.; Zhu, J.; Zhang, W.; Zhu, X.L., Atrp of MMA Under Co-60 Gamma-Irradiation at Room Temperature, Journal of Polymer Science Part A: Polymer Chemistry, 49, 16, 2011, 3588-3594.
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Record 10 of 42
| Record #: | 526 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | lithium trifluoroacetate (LiTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | By the mixing of THF solutions of PS (10 mg mL-1), silver trifluoroacetate (10 mg mL-1), and dithranol as a matrix (20 mg mL-1) in a ratio of 2:1:2 (matrix/cation/polymer). In a similar manner, PMMA and PMMA-d8 were prepared for analysis, except that lithium trifluoroacetate was the cation source and the ratio (matrix/cation/polymer) was 20:1:20 by volume |
Wyzgoski, F.J.; Polce, M.J.; Wesdemiotis, C.; Arnould, M.A., Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Investigations of Polystyrene and Poly(Methyl Methacrylate) Produced by Monoacylphosphine Oxide Photoinitiation, Journal of Polymer Science Part A: Polymer Chemistry, 45, 11, 2007, 2161-2171.
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Record 11 of 42
| Record #: | 522 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dihydroxybenzoic acid (DHB) (27138-57-4) |
| Salt: | sodium iodide (NaI), silver trifluoroacetate (AgTFA), or AgNO3 |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Dihydroxybenzoic acid (DHBA; 10 mg/mL THF) was used as a matrix, and LiCl salt was used to enhance the ionization. The polymer was dissolved in THF (3 mg/mL THF). |
Gnaneshwar, R.; Sivaram, Swaminathan, End-Functional Poly(Methyl Methacrylate)s via Group Transfer Polymerization, Journal of Polymer Science Part A: Polymer Chemistry, 45, 12, 2007, 2514-2531.
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Record 12 of 42
| Record #: | 8 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-dihydroxybenzoic acid (DHB) (490-79-9) |
| Salt: | cesium iodide |
| Solvent: | acetone |
| Recipe | Dissolve polymer in acetone to produce 1 x 10 -5 M solution of 260 K polymer, 2 x 10-5 M solution of 127 K polymer, or 1 x 10-4 M for molecular weights below 60 K. Matrix solution 0.2 M in acetone is mixed with polymer solution 5:1 (v/v). Place 0.5 to 2 mL on sample holder and air dry. |
Danis, P.O.; Karr D.E., A Facile Sample Preparation for the Analysis of Synthetic Organic Polymers by Matrix-Assisted Laser-Desorption Ionization, Organic Mass Spectrometry, 28, 8, 1993, 923-925.
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Record 13 of 42
| Record #: | 670 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | zinc oxide (ZnO) (1314-13-2) |
| Salt: | N/A |
| Solvent: | N/A |
| Recipe | Each 0.6 µl of the ZnO dispersed solution and analyte solutions were placed on a stainless-steel sample target and dried at room temperature. NaI (0.1 mM) was added to all sample solutions as cationizing agent. The optimum [ZnO nanoparticle] density ρ was found to be approximately 0.2 µg/mm2. |
Watanabe, T.; Kawasaki, H.; Yonezawa, T.; Arakawa, R., Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (Saldi-MS) of Low Molecular Weight Organic Compounds and Synthetic Polymers Using Zinc Oxide (Zno) Nanoparticles, Journal of Mass Spectrometry, 43, 8, 2008, 1063-1071.
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Record 14 of 42
| Record #: | 1064 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | trans-2-[3-(4-tert-Butylphenyl)-2-methylprop-2-enylidene]malononitrile (2-[(2E)-3-(4-tert-Butylphenyl)-2-methylprop-2-enylidene]malononitrile (DCTB)) (300364-84-5) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Equal volumes of a solution of PMMA (10 mg mL–1) in THF and a solution of DCTB in THF (20 mg mL–1) were mixed and then sodium trifluoroacetate was added. The resulting solution (1 μL) was applied to a stainless steel target plate. |
Grishin, I.D.; Turmina, E.S.; D'iachihin, D.I.; Vinogradov, D.S.; Piskunov, A.V.; Smolyakov, A.F.; Dolgushin, F.M.; Chizhevsky, I.T.; Grishin, D.F., Efficient Catalytic Systems Based on Paramagnetic Closo-Ruthenacarboranes for the Controlled Synthesis of Polymers, Russian Chemical Bulletin, 60, 11, 2011, 2375-2383.
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Record 15 of 42
| Record #: | 524 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrices: | 6-tert-butyl-2,3-naphthalenedicarbonitrile (32703-82-5) 4,4‘-methylenebis(N,N-diglycidylaniline) (28768-32-3) N-(4-nitrobenzoyl)-L-glutamic acid diethyl ester (7148-24-5) |
| Salt: | sodium iodide (NaI) |
| Solvent: | acetone, chloroform |
| Recipe | Matrixes in the respective solvents (10 mg/mL) were deposited as first layers on the MALDI target. NaI (100 mg/mL in acetone) was used as a second layer and PMMA (10 mg/mL in CHCl3) as final layer of the sample for the screening. For subsequent experiments involving different polymers, the polymer concentration was 20 mg/mL in CHCl3. |
Meier, M.A.R.; Adams, N.; Schubert, U.S., Statistical Approach to Understand MALDI-TOF-MS Matrices: Discovery and Evaluation of New MALDI Matrices, Analytical Chemistry, 79, 3, 2007, 863-869.
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Record 16 of 42
| Record #: | 523 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | α-cyano-4-hydroxycinnamic acid (CHCA) (28166-41-8) |
| Salt: | sodium iodide (NaI) |
| Solvent: | tetrahydrofuran/water |
| Recipe | PEG (1.8 mg/mL) was dissolved in water, CHCA (10 mg/mL), and NaI (1.5 mg/mL) in THF/water (1/1, v/v). Solutions containing the matrix, cationizing agent, and polymers (0.5 mL) were deposited on a stainless sample target by the overlayer method, as follows; first deposition, matrix solution;second, cationizing agent solution; third, polymer solution. |
Kawasaki, H.; Takeda, Y.; Arakawa, R., Mass Spectrometric Analysis for High Molecular Weight Synthetic Polymers Using Ultrasonic Degradation and the Mechanism of Degradation, Analytical Chemistry, 79, 11, 2007, 4182-4187.
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Record 17 of 42
| Record #: | 667 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2-[(2E)-3-(4-tert-Butylphenyl)-2-methylprop-2-enylidene]malononitrile (DCTB) (300364-84-5) |
| Salt: | sodium iodide (NaI) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | PMMA (10 mg · mL−1) in chloroform, DCTB (10 mg · mL−1) in THF, and the doping salt (NaI) dissolved in acetone at a concentration of 100 mg · mL−1 were used, and a multiple-layer spotting technique (matrix, salt, and analyte) was applied. Each layer was air dried before the next layer was spotted onto the previous one. |
Baumgaertel, A.; Becer, C.R.; Gottschaldt, M.; Schubert, U.S., MALDI-TOF MS Coupled with Collision-Induced Dissociation (Cid) Measurements of Poly(Methyl Methacrylate), Macromolecular Rapid Communications, 29, 15, 2008, 1309-1315.
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Record 18 of 42
| Record #: | 782 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-dihydroxybenzoic acid (DHB) (490-79-9) |
| Salt: | silver trifluoracetate (AgTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | PMMA 5 mg/mL, 40 mg/mL DHB, 5 mg/mL NaTFA. Samples were deposited onto MALDI targets using an Eppendorf 0.1–2.5 μL micropipettor (MP) in sizes ranging 100–500 nL,or a nanoliter Induction Based Fluidics (IBF) device in sizes ranging 100–500 nL, or a KDS-100 single syringe basic infusion pump (SP) (Holliston, MA) size of 100 nL. |
Hilker, B.; Clifford, K.J.; Sauter, A.D.; Sauter, A.D.; Gauthier, T.; Harmon, J.P., Electric Field Enhanced Sample Preparation for Synthetic Polymer MALDI-TOF Mass Spectrometry via Induction Based Fluidics (Ibf), Polymer, 50, 4, 2009, 1015-1024.
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Record 19 of 42
| Record #: | 7 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-dihydroxybenzoic acid (DHB) (490-79-9) |
| Salt: | sodium chloride |
| Solvent: | acetone:water (1:1) |
| Recipe | Poly(methyl methacrylate) is dissolved in either chloroform or acetone at a concentration of approximately 20 pmol/µL. Matrix solution is prepared at a concentration of 5mg/mL. 2 µL of polymer solution is mixed with 8 µL of matrix solution. Approximately 0.5 µL of the sample/matrix mixture are spotted onto the target under ambient conditions. |
Danis, P.O.; Karr, D.E.; Westmoreland, D.G.; Piton, M.C.; Christie, D.I.; Clay, P.A.; Kable, S.H.; Gilbert, R.G., Measurement of Propagation Rate Coefficients Using Pulsed-Laser Polymerization and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Macromolecules, 26, 24, 1993, 6684-6685.
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Record 20 of 42
| Record #: | 36 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 1,8,9-Anthracenetriol (dithranol) (1143-38-0) |
| Salt: | sodium iodide |
| Solvent: | 1,1,1,3,3,3-hexa-fluoro-isopropanol |
| Recipe | Polymer is dissolved in THF and matrix and salt added. Resulting mixture is deposited on sample probe and air-dried. |
Jackson, A.T.; Yates, H.T.; Scrivens, J.H.; Critchley, G.; Brown, J.; Green, M.R.; Bateman, R.H., The Application of Matrix-Assisted Laser Desorption/Ionization Combined with Collision-Induced Dissociation to the Analysis of Synthetic Polymers, Rapid Communications in Mass Spectrometry, 10, 13, 1996, 1668-1674.
doi:10.1002/(SICI)1097-0231(199610)10:13<1668::AID-RCM703>3.0.CO;2-I
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Record 21 of 42
| Record #: | 129 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | lithium trifluoroacetate |
| Solvent: | N/A |
| Recipe | Polymer is dissolved in THF to make 10-100 µmol solutions. Matrix is dissolved in THF at approximately 10 mg/mL. The solutions are mixed 3:1 matrix to polymer ratio and 0.5 µL is spotted on the target, or 0.7 µL of matrix solution is dried on the target and 0.4 µL of polymer solution is added to the dried matrix. |
Trimpin, S.; Rouhanipour, A.; Az, R.; Rader, H.J.; Müllen, K., New Aspects in Matrix-Assisted Laser Desorption/Ionizationn Time-of-Flight Mass Spectrometry: A Universal Solvent-Free Sample Preparation, Rapid Communications in Mass Spectrometry, 15, 15, 2001, 1364-1373.
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Record 22 of 42
| Record #: | 300 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrices: | nicotinic acid (59-67-6) 2,5-dihydroxy-p-benzoquinone (DHBQ) (615-94-1) 2,5-dihydroxybenzoic acid (DHB) (490-79-9) α-cyano-4-hydroxycinnamic acid (CHCA) (28166-41-8) sinapinic acid (SA) (530-59-6) nor-harmane (244-63-3) 2',4',6'-trihydroxyacetophenone (THAP) (480-66-0) trans-indoleacrylic acid (IAA) (29953-71-7) 2-(4-Hydroxyphenlyazo)benzoic acid (1634-82-8) |
| Salt: | sodium trifluoroacetate (NaTFA), silver trifluoroacetate (AgTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Polymer samples for MALDI analysis were prepared at a concentration of 0.5-0.6 mM in THF. The matrix solutions were prepared at a concentration of 60-70 mM in THF. The cationization reagent, sodium trifluoroacetate (NaTFA) for PEG and PMMA, was prepared at 0.7 mM in THF. The cationization reagent silver trifluoroacetate (AgTFA) for PS, was prepared at 0.9 mM in THF. The samples were prepared by mixing the polymer solution with matrix solution and cationization reagent solution at a volume ratio of 1:9:1, resulting in an effective matrix/analyte mole ratio in the range of 1000:1-1200:1. A 0.5 µL aliquot of the mixture was deposited on a sample plate and allowed to air-dry. |
Hoteling, A.J.; Erb, W.J.; Tyson, R.J.; Owens, K.G., Exploring the Importance of the Relative Solubility of Matrix and Analyte in MALDI Sample Preparation Using HPLC, Analytical Chemistry, 76, 17, 2004, 5157.
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Record 23 of 42
| Record #: | 301 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrices: | nicotinic acid (59-67-6) 2,5-dihydroxy-p-benzoquinone (DHBQ) (615-94-1) 2,5-dihydroxybenzoic acid (DHB) (490-79-9) α-cyano-4-hydroxycinnamic acid (CHCA) (28166-41-8) sinapinic acid (SA) (530-59-6) nor-harmane (244-63-3) 2',4',6'-trihydroxyacetophenone (THAP) (480-66-0) trans-indoleacrylic acid (IAA) (29953-71-7) 2-(4-Hydroxyphenlyazo)benzoic acid (1634-82-8) |
| Salt: | sodium trifluoroacetate (NaTFA), silver trifluoroacetate (AgTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Polymer samples for MALDI analysis were prepared at a concentration of 0.5-0.6 mM in THF. The matrix solutions were prepared at a concentration of 60-70 mM in THF. The cationization reagent, sodium trifluoroacetate (NaTFA) for PEG and PMMA, was prepared at 0.7 mM in THF. The cationization reagent silver trifluoroacetate (AgTFA) for PS, was prepared at 0.9 mM in THF. The samples were prepared by mixing the polymer solution with matrix solution and cationization reagent solution at a volume ratio of 1:9:1, resulting in an effective matrix/analyte mole ratio in the range of 1000:1-1200:1. A 0.5-L aliquot of the mixture was deposited on a sample plate and allowed to air-dry. |
Hoteling, A.J.; Erb, W.J.; Tyson, R.J.; Owens, K.G., Exploring the Importance of the Relative Solubility of Matrix and Analyte in MALDI Sample Preparation Using HPLC, Analytical Chemistry, 76, 17, 2004, 5157.
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Record 24 of 42
| Record #: | 369 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium trifluoracetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Polymer samples for MALDI analysis were prepared at a concentration of 5 mg/mL in tetrahydrofuran (THF; unstabilized). The matrix solution (dithranol) was prepared at a concentration of 28 mg/mL (0.15M) in THF. The cationization reagent, NaTFA, was prepared at a concentration of 1 mg/mL in THF. The samples were prepared through the mixing of the polymer solution with the dithranol solution and NaTFA solution at a volume ratio of 1:7:1. The mixture (0.5 µL) was deposited onto a sample plate and allowed to air-dry. |
Mourey, T.H.; Hoteling, A.J.; Balke, S.T.; Owens, K.G., Molar Mass Distributions of Polymers from Size Exclusion Chromatography and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry: Methods for Comparison, Journal of Applied Polymer Science, 97, 2, 2005, 627-369.
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Record 25 of 42
| Record #: | 778 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-dihydroxybenzoic acid (490-79-9) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Polymer samples, 2,5-dihydroxybenzoic acid (used as matrix) and sodium trifluoroacetate (used as a cationic agent) were dissolved in THF (10 mg · ml−1 solutions of each component) and the resulting solutions were mixed at 100/100/1 volume ratio. |
Kavitha, A.A.; Singha, N.K., Atom Transfer Radical Polymerization (Atrp) of Methyl Methacrylate Using a Functional Initiator Bearing an Amino-Adamantane, Macromolecular Chemistry and Physics, 210, 18, 2009, 1536-1543.
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Record 26 of 42
| Record #: | 37 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 1,8,9-Anthracenetriol (dithranol) (1143-38-0) |
| Salt: | rubidium trifluoroacetate |
| Solvent: | tetrahydrofuran |
| Recipe | Probe tips are loaded with 100 pmol polymer and 300 nmol matrix. |
Martin, K.; Spickermann, J.; Rader, H.J.; Mullen, K., Why Does Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Give Incorrect Results for Broad Polymer Distributions?, Rapid Communications in Mass Spectrometry, 10, 12, 1996, 1471-1474.
doi:10.1002/(SICI)1097-0231(199609)10:12<1471::AID-RCM693>3.0.CO;2-X
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Record 27 of 42
| Record #: | 779 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Samples for the MALDI-TOF MS were prepared by mixing the polymer (10 mg mL−1, 30 μL), the matrix (1,8-dihiydroxy-9(10H)-anthracenone, 30 mg mL−1, 90 μL), and the cationizing agent (sodium trifluoroacetate, 10 mg mL−1, 30 μL) in THF. |
Kakuchi, R.; Chiba, K.; Fuchise, K.; Sakai, R.; Satoh, T.; Kakuchi, T., Strong Bronsted Acid as a Highly Efficient Promoter for Group Transfer Polymerization of Methyl Methacrylate, Macromolecules, 42, 22, 2009, 8747-8750.
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Record 28 of 42
| Record #: | 1062 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 1,8-dihydroxy-9(10H)-anthracenone (1143-38-0) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Samples for the MALDI–TOF MS were prepared by mixing the polymer (10 mg mL–1, 30 μL), the matrix (1,8-dihydroxy-9(10H)-anthracenone, 30 mg mL–1, 90 μL) and the cationizing agent (sodium trifluoroacetate, 10 mg mL–1, 30 μL) in THF. |
Kakuchi, T.; Chen, Y.G.; Kitakado, J.; Mori, K.; Fuchise, K.; Satoh, T., Organic Superbase as an Efficient Catalyst for Group Transfer Polymerization of Methyl Methacrylate, Macromolecules, 44, 12, 2011, 4641-4647.
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Record 29 of 42
| Record #: | 1065 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Samples were prepared by mixing a THF solution a polymer (10 mg/mL), dithranol (10 mg/mL), and sodium trifluoroacetate (5 mg/mL) in a ratio of 1:1:1. |
Nakamura, Y.; Kitada, Y.; Kobayashi, Y.; Ray, B.; Yamago, S., Quantitative Analysis of the Effect of Azo Initiators on the Structure of Alpha-Polymer Chain Ends in Degenerative Chain-Transfer-Mediated Living Radical Polymerization Reactions, Macromolecules, 44, 21, 2011, 8388-8397.
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Record 30 of 42
| Record #: | 304 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrices: | 1,8-dihydroxy-9(10H)-anthracenone (dithranol) (1143-38-0) 2,5-dihydroxybenzoic acid (DHB) (490-79-9) |
| Salt: | silver trifluoracetate (AgTFA) |
| Solvent: | tetrahydrofuran (THF) and acetonitrile |
| Recipe | Samples were prepared by one of two methods, either deposited by dried droplet or electrosprayed onto a stainless steel target substrate. Approximately 0.3 to 0.5 µL of solution per sample site was placed on the target when samples were prepared by dried droplet. It was helpful to view the target through a stereo microscope (Fisher Scientific, Pittsburg, PA) while depositing the sample solution onto the target. Solution was delivered to the surface using a 5 µL glass capillary pipette (Drummond Scientific, Broomall, PA). Solvent was evaporated at room temperature in still air. No additional measures were taken to speed up or slow the solvent evaporation. |
Hanton, S.D.; Hyder, I.Z.; Stets, J.R.; Owens, K.G.; Blair, W.R.; Guttman, C.M.; Giuseppetti, A.A., Investigations of Electrospray Sample Deposition for Polymer MALDI Mass Spectrometry, Journal of the American Society for Mass Spectrometry, 15, 2, 2004, 168.
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Record 31 of 42
| Record #: | 939 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2-(4-hydroxyphenylazo)benzoic acid (1634-82-8) |
| Salt: | sodium chloride (NaCl) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Samples were prepared with 2-(4-hydroxyphenylazo)benzoic acid as matrix. In a vial, 25 mg matrix were dissolved in 1 mL THF. Separate solutions of polymer and NaCl (2 mg/mL in deionized H2O) were prepared. The solution for the analysis was obtained by mixing the matrix, sample and salt |
Fleischmann, S.; Percec, V., SET-LRP of Methyl Methacrylate Initiated with Sulfonyl Halides, Journal of Polymer Science Part A: Polymer Chemistry, 48, 10, 2010, 2236-2242.
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Record 32 of 42
| Record #: | 525 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Solutions of 40 mg dithranol/mL, 5 mg sodium trifluoroacetate/mL, and 1 mg polymer/mL in THF were prepared. The respective solutions were mixed in a ratio 5 : 1 : 5 on a volume basis. Enough of the mixture was applied to the sample position to cover the 2.5 mm diameter sample position (typically 0.3 μL). The spot was allowed to air-dry without any assistance |
Singha, N.K.; German, A.L., Pseudohalogens in Atom Transfer Radical Polymerization of Methyl Methacrylate, Journal of Applied Polymer Science, 103, 6, 2007, 3857-3864.
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Record 33 of 42
| Record #: | 302 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium trifluoracetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Solutions of 40 mg dithranol/ml, 5 mg sodium trifluoroacetate/ml, and 1 mg polymer/ml in THF were prepared. The respective solutions were mixed in a ratio 5:1:5 on a volume basis. Enough of the mixture was applied to the sample position to cover the 2.5 mm diameter sample position (typically 0.3 µL). The spot was allowed to air-dry without any assistance. |
Singha, N.K.; Rimmer, S.; Klumperman, B., Mass Spectrometry of Poly(Methyl Methacrylate) (PMMA) Prepared by Atom Transfer Radical Polymerization (Atrp), European Polymer Journal, 40, 1, 2004, 159.
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Record 34 of 42
| Record #: | 668 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | α-cyanohydroxycinnamic acid (28166-41-8) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | Spectra were obtained by using 0.1 M α-cyanohydroxycinnamic acid as the matrix in a 5 to 1 ratio of matrix to PMMA standard (0.1 mM). Manuscript compares MALDI to desorption ionization on silicon (DIOS). |
Gorman, C.B.; Petrie, R.J.; Genzer, J., Effect of Substrate Geometry on Polymer Molecular Weight and Polydispersity During Surface-Initiated Polymerization, Macromolecules, 41, 13, 2008, 4856-4865.
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Record 35 of 42
| Record #: | 217 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile (2-[(2E)-3-(4-tert-Butylphenyl)-2-methylprop-2-enylidene]malononitrile (DCTB)) (300364-84-5) |
| Salt: | sodium trifluoracetate (NaTFA) and silver trifluoracetate (AgTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | The matrix is trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile (DCTB), which was synthesized according to literature procedures.33 Sodium trifluoroacetate (Aldrich, 98%) and silver trifluoroacetate (Aldrich, 98%) were added to pMMA and pSt, respectively, as cationization agents. The matrix was dissolved in THF at a concentration of 40 mg mL-1. Salt was added to THF at typical concentrations of 1 mg mL-1. Polymer was dissolved in THF at approximately 1 mg mL-1. In a typical MALDI-ToF-MS analysis the matrix, salt and polymer solution were premixed in a ratio of 10:1:5. The premixed solutions were handspotted on the target well and left to dry. |
Willemse, R.X.E.; Staal, B.B.P.; van Herk, A.M.; Pierik, S.C.J.; Klumperman, B., Application of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry in Pulsed Laser Polymerization. Chain-Length-Dependent Propagation Rate Coefficients at High Molecular Weight: an Artifact Caused by Band Broadening in Size Exclusion Chromatography?, Macromolecules, 36, 26, 2003, 9797.
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Record 36 of 42
| Record #: | 303 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile (DCTB) (300364-84-5) |
| Salt: | sodium iodide (NaI) |
| Solvent: | N/A |
| Recipe | The matrix, trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile (DCTB, first layer) as well as the salt sodium iodide (NaI, second layer) were spotted by hand. Finally, the polymers were spotted automatically from the samples (taken during the polymerization) onto the MALDI-TOFMS target. |
Fijten, M.W.M.; Meier, M.A.R.; Hoogenboom, R.; Schubert, U.S., Automated Parallel Investigations/Optimizations of the Reversible Addition-Fragmentation Chain Transfer Polymerization of Methyl Methacrylate, Journal of Polymer Science Part A: Polymer Chemistry, 42, 22, 2004, 5775-5783.
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Record 37 of 42
| Record #: | 35 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-dihydroxybenzoic acid (DHB) (490-79-9) |
| Salt: | trifluoroacetic acid |
| Solvent: | tetrahydrofuran |
| Recipe | The polymer is dissolved in THF at a concentration of 1 mg/mL. 10 g of matrix is dissolved in 1 L of a mixture of equal volumes of ethanol and water, with an overall concentration of 0.1% trifluoroacetic acid. 0.5 µL of matrix solution is applied to a stainless steel slide and dried. The same volume of the polymer solution is applied to the dry matrix and the entire mixture is allowed to dry. |
Lehrle, R.S.; Sarson, D.S., Degradation and Selective Desorption of Polymer can Cause Uncertainty in MALDI (Matrix-Assisted Laser Desorption Ionisation) Measurements, Polymer Degradation and Stability, 51, 1996, 197-204.
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Record 38 of 42
| Record #: | 31 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | 2,5-dihydroxybenzoic acid (DHB) (490-79-9) |
| Salt: | alkali trifluoroacetates (Li, Na, K, Rb, Cs) |
| Solvent: | tetrahydrofuran |
| Recipe | The polymer is dissolved in THF at a concentration of 10-4 mol/L and mixed with equal volume (10 µL) of a 0.1 mol/L THF matrix solution. 1.5 µL of lithium trifluoroacetate solution at 5 mg/mL is added. 1 µL of the resulting mixture is placed on the target and air dried. |
Spickermann, J.; Martin, K.; Räder, H.J.; Müllen, K.; Schlaad , H.; Müller, A.H.E.; Kruger, R.P., Quantitative Analysis of Broad Molecular Weight Distributions Obtained by Matrix-Assisted Laser Desorption Ionisation-Time-of-Flight Mass Spectrometry, European Journal of Mass Spectrometry, 2, 3, 1996, 161-165.
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Record 39 of 42
| Record #: | 665 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium iodide (NaI) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | The polymer solutions (2–5 g L−1) were prepared in THF. The matrix, 1,8-dihydroxy-9[10H]-anthracenone (dithranol), was also dissolved in THF (25 g L−1). A 10 μL portion of the polymer solution was mixed with 20 μL of the matrix solution. A sodium iodide solution (10 μL of a solution at 20 g L−1 in THF) was finally added to favor ionization by cation attachment. 1 μL of the final solution was deposited onto the sample target and allowed to dry in air at room temperature. |
Dire, C.; Belleney, J.; Nicolas, J.; Bertin, D.; Magnet, S.; Charleux, B., Beta-Hydrogen Transfer from Poly(Methyl Methacrylate) Propagating Radicals to the Nitroxide Sg1: Analysis of the Chain-End and Determination of the Rate Constant, Journal of Polymer Science Part A: Polymer Chemistry, 46, 18, 2008, 6333-6345.
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Record 40 of 42
| Record #: | 666 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrices: | 2,5-dihydroxybenzoic acid (DHB) (490-79-9) α-cyano-4-hydroxycinnamic acid (CHCA) (28166-41-8) ferulic acid (FA) (1135-24-6) indole acrylic acid (IAA) (1204-06-4) dithranol (1143-38-0) diphenyl butadiene (DPBD) [Note: No CAS] |
| Salt: | sodium trifluoroacetate (NaTFA) or silver trifluoroacetate (AgTFA) |
| Solvent: | none (solvent-free) |
| Recipe | The vortex method involves adding the dry components of the analyte (about 0.1– 0.2 mg), matrix (20–40 mg), and cationization agent (trace to 0.1 mg) to a small glass vial. We typically add the analyte first, followed by the matrix and then the cationization agent, but there is no clear reason why the order of addition would matter to these experiments. Two BBs (premium grade, 4.5 mm Zn plated, ultra smooth, steel air gun shot [manufacture's name given] are then added to the vial. The contents in the vial are mixed on a vortex mixer for 60 s. A small spatula is used to remove a few grains of the mixed sample from the vial and transfer a few grains to the MALDI target. Using the flat edge of the spatula, and moderate pressure, we flatten the grains of material on the target in a circular pattern. This process requires only a few rotations and creates a thin film about 2–3 mm in diameter. Once a thin film is observed on the target, sufficient material is present for the MALDI experiment. Any extra material is removed from the target by gently tapping the target on the benchtop. Apparently the majority of the material originally transferred to the target is removed during tapping. A minority of the material forms the thin film for further analysis. |
Hanton, S.D.; McEvoy, T.M.; Stets, J.R., Imaging the Morphology of Solvent-Free Prepared MALDI Samples, Journal of the American Society for Mass Spectrometry, 19, 6, 2008, 874-881.
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Record 41 of 42
| Record #: | 940 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | dithranol (1143-38-0) |
| Salt: | sodium trifluoroacetate (NaTFA) |
| Solvent: | tetrahydrofuran (THF) |
| Recipe | [Semi-online LC/MALDI-MS sample preparation] Sample solutions of 20 mg/mL were prepared and 100 nL of the solutions were introduced into the sample injector. The eluent flow rate was 1.0 µL/min. The matrix (10 mg/mL) and cationization agent (50 µM) were added at a flow rate of 3.0 µL/min postcolumn to mix with the eluent. [T]he elution tip of the capillary column was fixed and the MALDI sample plate was manually transferred at a defined time interval. The eluate was dropped directly onto the sample plate at 15 s intervals (1 µL/spot) and dried in air at room temperature. The eluate content was 0.25 µL from the column and 0.75 µL from the mixture solvent of a matrix and a cationization agent. In all experiments, THF was used for dissolution of the matrix and the cationization agent. |
Watanabe, T.; Nakanishi, K.; Ozawa, T.; Kawasaki, H.; Ute, K.; Arakawa, R., Semi-Online Nanoflow Liquid Chromatography/Matrix-Assisted Laser Desorption Ionization Mass Spectrometry of Synthetic Polymers Using an Octadecylsilyl-Modified Monolithic Silica Capillary Column, Rapid Communications in Mass Spectrometry, 24, 13, 2010, 1835-1841.
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Record 42 of 42
| Record #: | 781 |
| Class ID: | 2.1 |
| Class Name: | acrylic polymer |
| Polymer: | poly(methyl methacrylate) (PMMA) |
| Matrix: | indole acrylic acid (IAA) (1204-06-4) |
| Salt: | sodium trifluoroacetate (NaTFA) or silver trifluoroacetate (AgTFA) |
| Solvent: | solvent-free |
| Recipe | [Using] the vortex method, we combined dry components of the analyte (about 0.1– 0.2 mg), matrix (20–40 mg), and cationization agent (trace to 0.1 mg) in a small glass vial, added two small metal balls, and mixed on a vortex mixer for a variable amount of time. We obtained data on samples mixed for 2–60 s. After mixing, the samples are applied to the MALDI target with a spatula to form a thin film. |
Hanton, S.D.; Stets, J.R., Determining the Time Needed for the Vortex Method for Preparing Solvent-Free MALDI Samples of Low Molecular Mass Polymers, Journal of the American Society for Mass Spectrometry, 20, 6, 2009, 1115-1118.
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